What should be the timing of initiation for SGLT2 inhibitors in patients with acute heart failure and how should Neprilysin inhibitors be used in acute heart failure with these two new therapies?

Dr Sim: There is an ongoing trial looking at the use of SGLT2 inhibitors in acute heart failure settings. The result should be out in a couple of years. In acute heart failure setting (like the design in PIONEER–HF trial), after the first 24 to 48 hours when the patient is stabilised in terms of the […]

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How should we use NT-proBNP guided therapy and anticipate that NT-proBNP is augmented in patients with chronic heart failure and acute kidney injury?

Dr Sim : Most of the time in Singapore, when a patient is received from the emergency department, an NT-proBNP would have been done. ED physicians are very aggressive in ordering the NT-proBNP so that the results would be quick. In the setting of pneumonia, acute kidney injury, they would definitely affect the NT-proBNP result. […]

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