Dr Januzzi: For chronic heart failure with reduced ejection fraction, the target is less than 1000 pg/mL. Below a 1000 pg/mL value, indicates ventricular remodelling begins to improve. That would be the target for chronic ambulatory heart failure.
For inpatient heart failure management, there is a wide range of values in patients that are hospitalised. 30% change is the biological variation of NT-proBNP. In the inpatient setting, due to lack of time, NT-proBNP values below a 1000 pg/mL are difficult to obtain, but a 30% reduction is considered a good sign. In the office or outpatient setting an absolute hard target of 1000 pg/mL and below is recommended.
