Dr Januzzi: In the early days, when NT-proBNP and BNP were first released, all of the NT-proBNP assays were quite similar in terms of reference ranges because they were all based on the same antibodies. The BNP assays out in the market are completely different; as they are based on different capture and detection antibodies. More lately, however, the assays for NT-proBNP are beginning to change a little bit, in terms of the results that they provide. It is important to recognize and understand that each lab may provide a different results and understanding how your lab differs from others is going to be important.
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